Oh no, they’re definitely compatible with it. Essentially, now, you have a single seed region (and a mask); so naturally, your streamlines will start nicely there, and follow along your bundle of interest for a while, and even the majority will follow it for quite a distance… but eventually, streamlines will branch off here and there from the bundle, creating the mess of spurious fibres you see. Even though they’re all over the place, they’re still very sparse (and not dense at all). Adding exclusion regions will help you to eliminate some of these spurious streamlines, given that you put them in strategic locations of course. Extra inclusion regions will help you constrain the bundle to better go towards a particular target (along a particular orientation and path). To get the SLF, 2 well positioned inclusion regions (vaguely around the ends of the the SLF) will already get you much further. That, I’d do as a first step. Then look at that result, and refine it by adding exclusion regions where necessary, should any “stubborn” streamlines still take a different route from the one inclusion region to the other inclusion region.
But again, this takes some hands-on attempts, so you can gradually refine your command (and the regions you draw); and at the same time get the experience to better predict up-front how tractography will behave for particular tasks, such as tracing the SLF.