Compare structural connectivity across subjects

Hi,
I would like to investigate whether the differences between structural connectivity matrices across subjects imply a different response to tDCS.

From literature I can’t find a ‘good practice’ to properly compare the SC in output from tck2connectome, or whether there is the necessity to normalize SC.

So far, I normalize the wm fod with mtnormalise, then I filter the whole brain tractogram with tcksift2 and in the end I obtain the SC with tck2connectome. Shall I do something else in order to compare SC matrices across subjects?

Thanks,
Giulia