DTI Multiple Sclerosis


I am working with a database of Mutliple Sclerosis patients and healthy subjects (3T). I should calculate FA and MD of both patients and healthy subjects. is it possible to do correlation analysis? Also I would like to see how the fiber bundles passing through the patients’ lesions communicate with the networks in a functional atlas. is it possible to import an atlas? if so should it be in MNI coordinates? and should the lesions be considered as ROIs?
Thanks for the help