We are just about to start recruiting for a large study which will be acquiring data from around 1000 cases over the next 4 years including diffusion. Obviously, we would like to use MRtrix for our analysis. My current computational sever setup takes around 20-24 hours to produce 100 million tracts for a single case. My question is: how long does it take other people to produce this number of tracts for a single case? If it is significantly quicker than 20 hours what is your computational setup, CPUs, RAM etc…? I am interested in this as we haven’t really set ourselves up for this yet and would like to get an idea of what is appropriate for the volume of analysis we will be performing.