Intensity Normalization question for a wide range gestational age

Hi , MRtrix experts
I am currently working on the dHCP newborn data with gestational age(GA) from 34-44, for each gestational age, we have equal size subjects number.

Now I want to look at the GA related changes of thalamus topological organization based on ODF coefficient, so before to get the ODF, should I do the intensity normalization for the whole cohort or separately for each age group? which normalization strategy would you recommend?? also similar question for the Mean Response function estimation

Thank you in advance!


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