Dear experts,
I am now very interested to investigate whether the result of tractography in my study I described in earlier post ever makes sense
I was considering to repeat the same experiment (all steps 1-5 I described in the post linked above, possibly also with manual tract filtering using anterior pons ROI) with nulldist2 algorithm in tckgen to determine if the streamline weights sum of auditory pathway obtained by tracking with measured FODs are significantly higher than when using nulldist2.
When I investigate one pathway, is my experiment targeted tracking or whole-brain tracking? Does the theory under Morris et al. paper apply for this case?
Thinking of that in principle: With SIFT2 on streamlines generated by nulldist2, how can I properly generate my isotropic FOD needed for SIFT2? I think that its integral cannot be constant, it should be modulated by either white matter content within the voxel (from 5tt) or by total FOD integral of my reconstructed FOD.
Does this experiment ever make sense to you?
Antonin