Population template Single-vs-Group

[m.bart]

Dear Robert!

Thanks for your time and your muse on the topic! Looking at it as at two separate points helped I have actually created a separate thread for a statistical comparison in 1-vs-group cases here (don’t get confused by number of subjects, I am experimenting with different quaility control evaluations - more or less strict) You will probably run into it after you will successfully dig through the piles of questions here . Need to mention that we all are grateful you are digging through them!

@rsmith

For point 2, I’m not personally convinced that the hypothesis “is this one subject different from the group (36 patients + 93 controls)” is of tremendous utility; the question “is this subject different to controls” feels far more intuitive.

At first, yes, by “group” I meant Control Group made of helthy controls. I never wanted to compare one epileptic patient to the group of mixed epi patients and healthy controls. My intention was to compare every single one patient to the group of healthy control subjects in an individual testing. Now I am thinking maybe I will compare one-healthy-control-subject to the-rest-of-the-healthy-controls as well, to see whether and how big effect I can see on healthy subjects. Sorry for confusion

Eventually, I have decided to make a template using 20 healthy controls and 20 patients (excluding ones with huge visible structural abnormalities) for a registration purposes (point 1).

@rsmith

the normative data against which the subject is to be compared based on selection of the appropriate fixel data.

However, I am not sure If I understand this last part correctly. By normative data you mean basically
to have a right set of subjects in a control group that are used to generate a null distribution against which individuals will be statistically compared, right? For patients, using FD, FC and FDC data from 92 out of 93 healthy control subjects (one randomly omited); for healhy subjects, comparing his/hers/its FD, FC and FDC to the ones of remaining 92 (without the one in a first group)?

Thanks!
Michaela.