I hope this question has not been asked before.
I am creating structural connectomes based on the Human Connectome Project pipeline. I saw some discussions on registering diffusion images to structural (T1) images on the forum, and I was wondering if this is a necessary step to take at the beginning of the pipeline.
On the website, it says if no diffusion distortion correction applied, then non-linear registration is an option to consider. For a diffusion image, I am using the ones that have been denoised and eddy-corrected, and generating tractography based on anatomically constrained tractography framework.
I ran 40 people so far, and 3 of them are missing about 4 nodes. I was wondering why that is the case. Is there a possibility that some subjects are missing nodes because I am not registering dwi images to T1 in my pipeline?
Hope this makes sense, and thank you!