Dear fellow MRtrix community members,

First a hugh compliment for the clarity of the documentation on performing fixel based morphometry!

I’ve been working through the documentation but I have a question about the last part: the CFE stats.

I have a 2x2 mixed design (2 groups, 2 time points) for which I need to prepare a design matrix. I read in this post: Design matrix for fixelcfestats

that I can follow the same rules as with the GLM specification in FSL. Nevertheless, the fsl documentation states that GLM, and randomise in particular, is ill equipped to handle a repeated measures design such as mine (https://fsl.fmrib.ox.ac.uk/fsl/fslwiki/GLM#ANOVA:*2-groups.2C_2-levels_per_subject*.282-way_Mixed_Effect_ANOVA.29).

Does this also apply to CFE stats or can I still (in some way or form) perform this analyses?

best wishes, Chris