Hey Daniel,
Yep, I’ve vaguely documented some ideas here a while ago: T1-like contrast from DWI data .
But I wouldn’t actually recommend to use this without a lot of experience in what’s going on here, as well as very careful QC. Generating the T1-like contrast itself is in some ways relatively straightforward actually, but it’s the registration for this particular purpose and sometimes in presence of certain particular pathologies, that is much harder to get right without a lot of experience in this area.
So while we did manage to get this right for a few particular studies at some point, I wouldn’t generally recommend to adopt this strategy broadly.
There’s a nice piece of work here though, and the software seems to be available: https://www.biorxiv.org/content/10.1101/2020.01.19.911784v1.full . It looks like quite an elegant approach with promising results. If you give it a go, I would actually love to hear if it works well for your data!
Cheers,
Thijs