Dear MRtrix experts,

I’m trying to compute differences between 2 groups in structural connectomes.

According to the documentation provided in the 1st Mrtrix workshop, once individual connectomes were generated, some small modifications of these individual connectomes were suggested in preparation for statistical inference.

Some of the steps suggested included calculating the group mean connectome (after scaling by mu), sorting the edge densities (excluding self-connections) and choosing the 80th-percentile value.

The question is, if I have 2 groups, should I calculate the mean (and sorting the densities etc ) for each group separately?

I was also wondering whether this procedure is up to date and whether new documentation is available on how to proceed in group connectomics.

Thanks in advance,

Ane