Dear Mrtrxi3 community,
I have one question regarding the interpretation of some FBA results using the log_FC quantitative metrics.
Lower magnitudes of fibre-bundle cross-section (FC) is typically found in neurodegenerative diseases, such as Alzheimer’s disease and Motor Neurone Disease, when these clinical populations are compared to healthy ones. To make it short, the common interpretation is that: lower FC = lower capacity of information transfer for the bundle of interest.
My question is:
Is this ‘always’ the case? Also for small interindividual differences on a population of healthy individuals? And can it ‘that’ be the only functional interpretation (pls, don’t hit me )?
In my study, I have noticed that interindividual differences in log_FC are particularly pronounced in the midsagittal line of the genu and splenium of the corpus callosum - the point where fibers from the two hemispheres converge. Here, I found that log_FC relate negatively (negative_ pFWE < 0.05) with auditory performances in an experimental task that might require interhemispheric interaction and communication. So, looking at that ‘interpretation’, my results seem to be a bit counterintuitive.
I’d like to have an opinion from you regarding the question (if not the results of my study, which I guess would harder to interpret). Also rising a doubt on this maybe ‘simplistic’ interpretation, the multiple factors that can affect FC (besides axon loss), or also pointing to relevant literature, could be of help.
Thank you in advance,