Dear MRtrix team,
I have a technical question regarding the estimation of response function and would appreciate your thoughts. I have successfully applied fixe-based analysis to a large sample of multi-shell dMRI data (b = 1000, 32 directions; b = 2500, 64 directions, intersected by 6 b100 volumes) from healthy controls and patients with Alzheimer’s disease. The results are as expected and in line with Mito et al 2018 findings. However, recently I came across this paper which made me think about the accuracy of the estimated response function based on which FODs and subsequent FBA metrics are calculated. The response function is a factor of SNR and seems to be affected in pathology. Could this affect the estimation of FBA metrics and the downstream analysis? Many thanks in advance for the clarification!