pathology and estimation of the response function

Dear MRtrix team,

I have a technical question regarding the estimation of response function and would appreciate your thoughts. I have successfully applied fixe-based analysis to a large sample of multi-shell dMRI data (b = 1000, 32 directions; b = 2500, 64 directions, intersected by 6 b100 volumes) from healthy controls and patients with Alzheimer’s disease. The results are as expected and in line with Mito et al 2018 findings. However, recently I came across this paper which made me think about the accuracy of the estimated response function based on which FODs and subsequent FBA metrics are calculated. The response function is a factor of SNR and seems to be affected in pathology. Could this affect the estimation of FBA metrics and the downstream analysis? Many thanks in advance for the clarification!

Best wishes,