Whole brain tractogram

Dear All,
I have ran the anatomically contrained tractography on my DTI data with bvalue =1000 and bvecs= 56 directions. where I get the attached SIFT corrected tractogram but I am not sure it is correct or not.
So plaese have a look and let me know your point of views.


Hi Neeraj,

The data look basically as expected:

  • Streamlines stringently constrained within WM and SGM due to the use of ACT.

  • Spatial distribution of streamlines density (gauged by the amount of “empty space” in between the streamlines) is approximately equal across the white matter; this is not explicitly a constraint in SIFT, but tends to be what the FOD data suggest, and also makes sense from a physical perspective (if one can fit a certain density of fibres within a given volume of white matter in one area of the brain, why would the density of fibres be grossly smaller or larger than this elsewhere in the WM?).

The low-ish b-value means that the interpretation of FOD amplitude (and concomitantly streamline count post-SIFT) can’t be interpreted as being proportional to intra-cellular volume / cross-sectional area with confidence… but applying SIFT nevertheless is likely still preferable to omitting that step.