Hello fellow mrtrix users!
Another question related to this topic. We are analysing data from two time-points in a cohort of ischemic stroke patients and we want to predict what white matter fibers will be affected. Then we would like to measure changes along these predicted fibers, such as changes in FA, FOD and fiber integrity between the two time points (an earier measurement post-stroke vs. a later measurement post-stroke). When we perform that, we would like to compare the observed changes to those in control areas and I have a bit of a conceptual question here: what areas would best represent control areas if the subjects have a stroke in a streamline that projects bilaterally? A lot of studies (in fact, most studies I read on the topic), typically measure asymmetry indexes on the ipsi- and contra-lateral side, i.e. a lesioned CST on one side, compared to the intact cortico-spinal tract in the other hemisphere. Certainly, for bilateral streamlines, using the contra-lateral (and contra-lesional side) won’t be that useful as a control area if we expect distal degenerative changes there too, over time. Would you have any recommendations?
Thank you very much in advance.